Genomic Microarray in Constitutional and Oncology Settings
Genomic microarray analysis has utility across multiple areas of medicine as a clinical test for both heritable (constitutional) and acquired (oncologic) genetic abnormalities. This presentation will provide an overview of both the technical and interpretive aspects of genomic microarray analysis in order to facilitate better understanding of the clinical utility of this test.
Originally presented on April 20, 2016 in Salt Lake City, Utah.
Erica Andersen, PhD
Medical Director, Cytogenetics and Genomic Microarray, ARUP Laboratories
Assistant Professor of Pathology, University of Utah School of Medicine
Dr. Andersen is an assistant professor of pathology at the University of Utah School of Medicine. She received her PhD in genetics from the University of Wisconsin–Madison and completed a clinical cytogenetics fellowship at the University of Utah. She is board certified by the American Board of Medical Genetics and Genomics and is a fellow of the American College of Medical Genetics and Genomics. Dr. Andersen’s interests include both constitutional and oncology cytogenetics. She is an active member of the Clinical Genome Resource (ClinGen) group’s efforts to improve constitutional structural variant interpretation, and her oncology research projects include improving the diagnosis and monitoring for myelodysplastic syndromes and understanding the genetic etiology of rare histiocytic and dendritic cell neoplasms.
After this presentation, participants will be able to:
- Provide an overview of the technical details and basic interpretation of results from genomic microarray analysis.
- Compare the utility of genomic microarray analysis to other genomic analysis techniques and understand the advantages, disadvantages and limitations of these tests.
- Understand the utility of genomic microarray for different clinical indications including diagnosis of heritable genetic conditions in children, adults, pregnancy and fetal loss and for diagnosis and monitoring in cancer.
University of Utah School of Medicine, Department of Pathology, and ARUP Laboratories