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HPV Testing For Cervical Cancer Screening
There are an estimated 12,000 cases and 4,200 deaths due to cervical cancer in the U.S. per year. The vast majority of cervical cancers are caused by persistent infections with human papillomavirus (HPV). While most HPV infections are transient, persistent infections with any of 14 high-risk types (HR-HPV) may lead to cervical cancer. Cervical cytology plus HR-HPV testing (co-testing) is now recommended for most women in cervical cancer screening guidelines published earlier this year by the American Cancer Society (ACS), the American Society for Colposcopy and Cervical Pathology (ASCCP), and American Society for Clinical Pathology (ASCP). There currently are 4 U.S. FDA-cleared assays for HR-HPV testing. This presentation will review the role of HR-HPV in cervical cancer development, the use of HR-HPV testing for cervical cancer screening in current guidelines, and provide an overview of FDA-cleared HR-HPV tests.
Originally presented to a group of Medical Laboratory Scientists on August 14, 2012 in Salt Lake City, Utah.
Robert Schlaberg, MD, MPH
Medical Director, Microbial Amplified Detection Laboratory, ARUP Laboratories
Assistant Medical Director, Virology and Molecular Infectious Disease Laboratories, ARUP Laboratories
Assistant Professor of Pathology, University of Utah School of Medicine
Dr. Schlaberg is the medical director of the Microbial Amplified Detection Laboratory and an assistant medical director of the Virology and Molecular Infectious Disease laboratories at ARUP, and an instructor of clinical pathology at the University of Utah School of Medicine. He received his MD and doctor medicinæ degrees at the Julius-Maximilians-University in Wuerzburg, Germany and his master of public health at the Mailman School of Public Health at Columbia University in New York City, where he also served as a postdoctoral fellow. Dr. Schlaberg trained in clinical pathology at the Columbia University College of Physicians & Surgeons, where he was the chief clinical pathology resident. He is certified in clinical pathology by the American Board of Pathology and was awarded the Young Investigator Award by the Academy of Clinical Laboratory Physicians and Scientists.
After this presentation, participants will be able to:
- Explain the role of HR-HPV in cervical cancer development.
- Explain the use of HR-HPV testing in current cervical cancer screening guidelines.
- Be able to compare testing principles used in current FDA-cleared HR-HPV assays.
University of Utah School of Medicine and ARUP Laboratories