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Myelodysplastic Syndrome and Acute Myeloid Leukemia
The Myelodysplastic Syndromes (MDS) and acute leukemias of myeloid, erythroid, and megakaryocytic origin are clonal bone marrow disorders. They are characterized by clinical, morphologic, immunophenotypic and cytogenetic features. The most current and well-accepted classification of these disorders is from the World Health Organization (WHO) published in 2008. This presentation will review these disorders with an emphasis on the pathologic diagnosis of each, including the use of laboratory methods for classification, management and prognostic assessment.
Originally presented August 16, 2012 in Salt Lake City, Utah.
Ronald L. Weiss, MD, MBA
Staff Hematopathologist, ARUP Laboratories
Professor of Pathology, University of Utah School of Medicine
Dr. Weiss served as ARUP's chief medical officer and director of laboratories from 1993 until 2002, director of business development from 2002 until 2003, president and chief operating officer from 2003 until 2009, and executive vice president from 2009 until 2010. Dr. Weiss is a professor of pathology at the University of Utah and is board certified in anatomic/clinical pathology, microbiology, and hematology by the American Board of Pathology. Dr. Weiss is past chairman of the board of the American Clinical Laboratory Association and past president of the American Pathology Foundation. He is a fellow of the College of American Pathologists and the American Society for Clinical Pathology. Dr. Weiss received his MD from Creighton University and an MBA from the University of Utah, where he completed his residency training.
After this presentation, participants will be able to:
- Understand the pathophysiology of myelodysplastic syndromes and acute myeloid leukemias.
- Review the current (WHO 2008) classification of these disorders.
- Understand the approach to the practical laboratory diagnosis of these disorders.
University of Utah School of Medicine and ARUP Laboratories