Diagnosing Hepatocellular Adenomas: A Case-Based Approach

This lecture offers the following credit types: CME, P.A.C.E.®, Florida
 

Well-differentiated hepatocellular lesions arising in the setting of noncirrhotic livers can pose a diagnostic dilemma for pathologists. This lecture will cover the five major subtypes of hepatocellular adenomas (HCAs), including: inflammatory, HNF1α-inactivated, β-catenin-activated, sonic hedgehog, and unclassified. This lecture will also cover the clinical significance of each subtype and the recommended clinical management. Finally, this lecture will review the differential diagnosis of hepatocellular adenomas and key points for reaching a pathologic diagnosis.

Originally published on April 2, 2026

Lecture Presenter

Katherine Boylan, MD

Katherine Boylan, MD

Assistant Professor (Clinical)
Spencer Fox Eccles School of Medicine at the University of Utah
Pathologist
ARUP Laboratories

Dr. Katherine Boylan is a medical director of anatomic pathology at ARUP Laboratories and an assistant professor (clinical) at the Spencer Fox Eccles School of Medicine at the University of Utah. Dr. Boylan received her medical degree from Charles E. Schmidt College of Medicine at Florida Atlantic University. She completed her residency in anatomic and clinical pathology at the University of Utah School of Medicine, and a fellowship in gastrointestinal and hepatobiliary pathology at the University of Chicago School of Medicine. Dr. Boylan is certified in anatomic and clinical pathology by the American Board of Pathology. She received an honorable mention award from the Rodger C. Haggitt Gastrointestinal Pathology Society for her Gastrointestinal Pathology – 2020 Abstract. Her research interests include sessile serrated polyps and the serrated colon cancer pathway, as well as pathology resident education.

Objectives

After this presentation, participants will be able to:

  • Recognize and diagnose the most common hepatocellular adenoma subtypes
  • Compare the clinical significance and management for each hepatocellular adenoma subtype
  • Identify the differential diagnosis for well-differentiated hepatocellular lesions in noncirrhotic livers

Sponsored by:

Spencer Fox Eccles School of Medicine at the University of Utah, Department of Pathology,
and ARUP Laboratories