Connect Sign InTurning Down the Volume: Strategies to Reduce Sample Volume From Babies to Adults
The need to restrict sample volume and frequency is obvious in children but less so in adults. Iatrogenic anemia is common in both populations. A major contributor is dead volume required by robotic sample processing. This session explores alternative collection techniques and sample types that preserve blood volume but do not compromise delivery of clinical information. The use of dried blood spots, volumetric absorptive microsampling, and the use of interstitial fluid will be addressed, among other novel methods. Emphasis will be placed on both short-term adaptations and the longer-term need for market-driven innovation to preserve blood volume.
Dennis J. Dietzen serves as division chief in Pathology and Laboratory Medicine and the Megan K. Dishop Endowed Chair in Pathology at Phoenix Children’s. Prior to this role, he was a professor of Pathology at Washington University and director of laboratories at St. Louis Children’s Hospital. A distinguished member of several professional organizations, including ADLM (formerly AACC), the Society for Pediatric Research, the Society for Inborn Metabolic Disorders, and the Academy of Clinical Laboratory Physicians and Scientists, Dr. Dietzen has been recognized for his contributions to pediatric clinical chemistry with the 2012 AACC Award and served as AACC President in 2018. His research centers on mass spectrometry applications in pediatrics, with a focus on drug screening, rapid detection of metabolic diseases, liver failure, preeclampsia, and neonatal hypoglycemia. He has authored over 100 peer-reviewed publications, monographs, editorials, and book chapters.
