Immunohistochemistry in Challenging Hematology Cases: Old Friends and New Acquaintances

For many years, immunohistochemistry (IHC) has played an essential role in diagnostic pathology. Advancements in our understanding of many diseases and increasing availability of targeted therapy have given the IHC technology a boost to evolve. This presentation is based on a series of diagnostically challenging cases referred to our hematopathology team by surgical pathologists. The diagnostic workup for these cases highlights newer applications of widely available IHC stains and also introduces recently developed markers.

Lecture Presenter
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Anton Rets, MD, PhD
Anton Rets, MD, PhD
Assistant Professor (Clinical) of Pathology, University of Utah School of Medicine
Medical Director, Hematopathology, ARUP Laboratories

Dr. Anton Rets is a medical director of Hematopathology at ARUP Laboratories and an assistant professor (clinical) at the University of Utah School of Medicine. Dr. Rets received a doctorate degree in pathology from Perm State Medical Academy/St. Petersburg Academy of Postgraduate Medical Education. He then earned his medical degree and completed a pathology residency at Perm State Medical Academy. He also completed an anatomic and clinical pathology residency at the State University of New York Downstate Medical Center before completing a hematopathology fellowship at the University of Utah School of Medicine. Dr. Rets is board certified in anatomic and clinical pathology and hematopathology. He has received several awards, including the Outstanding Teaching award in clinical pathology, the Excellence in Leadership award, and the Outstanding Academic Performance Federal award. His research interests include red blood cell disorders, mast cell disorders, nonneoplastic hematology, and digital microscopy.

Objectives

After this presentation, participants will be able to:

Demonstrate the utility of “traditional SurgPath” IHC markers in hematopathology practice
Discuss best practices in interpretating and reporting of some IHC stains
Review newer IHC stains in hematopathology
Construct diagnostic workup of morphologically challenging hematopathology cases