Hypocellular Bone Marrow: What’s Next?


Pathologic conditions characterized by peripheral cytopenia and bone marrow hypoplasia are not infrequent in community practice. The differential diagnosis usually includes many entities and the diagnostic work up may be very challenging. Increasing availability of molecular tests and emerging concepts of clonal hematopoiesis make the diagnostic investigation even more complex. The purpose of this presentation is to emphasize the importance of the diagnostic role of  a pathologist, and delineate a practical step-by-step approach to bone marrow failure conditions including malignant, constitutional and idiopathic disorders.

Originally presented on February 13, 2020 in Park City, Utah.

Lecture Presenter

Anton Rets, MD, PhD

Anton Rets, MD, PhD

Assistant Professor of Pathology (Clinical)
University of Utah School of Medicine
Medical Director
ARUP Laboratories

Dr. Rets is an assistant professor of pathology at the University of Utah School of Medicine. He received his MD and PhD at Perm State Academy of Medicine in Russia. He served as an anatomical and clinical pathology resident at State University of New York Health Science Center at Brooklyn and a hematopathology fellow at the University of Utah School of Medicine. Dr. Rets is board certified in hematopathology, anatomic pathology, and clinical pathology. He is also a member of several professional societies, including the College of American Pathologists and the American Society for Clinical Pathology. Dr. Rets’ professional interests include red blood cell disorders, non-neoplastic hematology, and precursor lymphoid neoplasms.


After this presentation, participants will be able to:

  • Identify the current definition of aplastic anemia and generate a comprehensive differential diagnosis
  • Describe diagnostically relevant morphologic features
  • Discuss currently available testing options and propose a practical diagnostic algorithm for bone marrow failure conditions

Sponsored by:

University of Utah School of Medicine, Department of Pathology, and ARUP Laboratories