Principles of Pharmacogenomics

 

Pharmacogenomics has been at the forefront of precision medicine during the last few decades. In this presentation, a historical overview will be presented. Then some basic principles relevant to pharmacogenomics together with a review of the relevant molecular methodologies with a comparison of their advantages and disadvantages will be discussed. Finally, some of the implementation challenges will be reviewed, some inherent to pharmacogenomics, while others are relevant to precision medicine initiatives in general.

Originally published on May 2, 2023

Lecture Presenter

Sherin Shaaban, MD, PhD, FACMG

Sherin Shaaban, MD, PhD, FACMG

Assistant Professor
University of Utah School of Medicine
Medical Director, Pharmacogenomics, Molecular Genetics and Genomics
ARUP Laboratories

Dr. Sherin Shaaban is the medical director of pharmacogenetics and molecular genetics at ARUP Laboratories and an assistant professor of pathology at the University of Utah School of Medicine. She received her medical degree from Mansoura University in Egypt and her doctorate degree in genetics from Okayama University in Japan, followed by a research fellowship in genetics at the Boston Children’s Hospital. She then completed a clinical fellowship in clinical molecular genetics at the Icahn School of Medicine at Mount Sinai. Dr. Shaaban is board certified by the American Board of Medical Genetics and Genomics. Prior to joining ARUP, Dr. Shaaban was a clinical assistant professor at the Sanford School of Medicine in South Dakota. Her research and academic interests focus on the implementation of molecular testing for rare inherited diseases and the validation and implementation of pharmacogenetics testing.

Objectives

After this presentation, participants will be able to:

  • Define pharmacogenetics/genomics (PGx)
  • Discuss pharmacogenes and possible genetic variations
  • Describe what molecular methodologies are used in the field
  • Discuss PGx implementation challenges

Sponsored by:

University of Utah School of Medicine, Department of Pathology, and ARUP Laboratories