MLS Topics

An 86 year-old male, O+, with a history of anemia presented with extreme fatigue in 2020 and significant weight loss. BMBx found erythroid megloblasoid maturation and abnormal cytogenetics. Diagnosed with low-grade Myelodysplastic syndrome. Severe anemia a year later, repeated BMBx and did not met MDS criteria. This presentation will further discuss the patient's case and labs along with diving into autoimmune hemolytic anemia.

Presented by 
Taylor S. Jackson, DO
Pathology Resident-PGY4; Spencer Fox Eccles School of Medicine at the University of Utah

This video is 18 min

An 81 year old, B positive female with a history of hemochromatosis, multiple sclerosis, IBS and was recently diagnosed with AML presents with a WBC 2.83k/uL, Hgb 7.5 g/dL, and platelets 6,000/uL. This case review will discuss human leukocyte antigens and how HLA antibodies affect transfusions.

Presented by
Taylor S. Jackson, DO
Pathology Resident-PGY4; Spencer Fox Eccles School of Medicine at the University of Utah

This video is 13 min

This lecture talks about Change Control and Validation.

Presented by 
Rebecca Whitney, MLS (ASCP)
Quality and Compliance Coordinator, Transfusion Medicine, ARUP Laboratories

This video is 9 min

This lecture talks about Compliance and Inspections of Blood Donor and Transfusion Medicine Laboratories.

Presented by 
Rebecca Whitney, MLS (ASCP)
Quality and Compliance Coordinator, Transfusion Medicine, ARUP Laboratories

This video is 9 min

This lecture talks about Current Good Manufacturing Practices.

Presented by 
Rebecca Whitney, MLS (ASCP)
Quality and Compliance Coordinator, Transfusion Medicine, ARUP Laboratories

This video is 16 min

A 65 year-old male, O+, admitted with a small bowel obstruction for 4 days. Two weeks later presented to ED with abdominal pain, chills, fatigue, etc. Lab reported hemolysis. Imaging showed hepatic abscess and cholecystitis. This presentation will further discuss the patient's labs and findings along with explore hemolysis and clostridium perfringens infection.

Presented by
Taylor S. Jackson, DO
Pathology Resident-PGY4; Spencer Fox Eccles School of Medicine at the University of Utah

This video is 14 min

This video will instruct you on the proper method to create Alsever's Solution for use in the blood bank.

Developed by the Institute for Learning, ARUP Laboratories

This video is 6 min

This video will instruct you on the proper method to read tubes for blood banking including grading reactions.

Developed by the Institute for Learning, ARUP Laboratories

This video is 6 min

This short video, created by Justin Rhees, MS, SBBCM, MLS(ASCP)^CM Assistant Professor with Weber State University, provides instructions on the proper method for inspecting donor RBC and plasma units.

Developed by the Institute for Learning, ARUP Laboratories

This video is 1 min

Blood transfusions are medical procedures used to treat cellular deficiencies and potentially life-threatening conditions such as massive blood loss, congenital disorders, malignancies, chonic anemias, and numerous other conditions. This video covers the general process for issuing blood products for infusion in patients.

Developed by the Institute for Learning, ARUP Laboratories

This video is 5 min

Fresh frozen plasma, or FFP, is the liquid portion of blood that has been prepared from a whole blood donation or apheresis collection and then frozen within 8 hours of procurement. This video will show the steps for choosing and thawing plasma.

Developed by the Institute for Learning, ARUP Laboratories

This video is 2 min

A 70-year-old male presents with on-going nosebleeds. They have a history of hypertension, diabetes mellitus type 2, gout, cronic sinusitis, aortic stenosis s/p aortic valve repair. Diagnosted with ITP ~ 5 to 10 years ago on rituximab. This presention will discuss this patient's diagnosis along with diving into immune thrombovytopenia.

Presented by 
Miranda Chimzar, MD
Pathology Resident-PGY2, Spencer Fox Eccles School of Medicine at the University of Utah

This video is 16 min

This lecture talks about Inspections of Blood Donor and Transfusion Medicine Laboratories.

Presented by 
Rebecca Whitney, MLS (ASCP)
Quality and Compliance Coordinator, Transfusion Medicine, ARUP Laboratories

This video is 23 min

37 year-old women at 29 weeks pregnant, type A+, 4 cm placental mass, polyhydramnios, and new concern for fetal anemia based on elevated MCA dopplers was admitted to be consulted for amnioreduction and intrauterine transfusion. This presention will further discuss this case along with explore intrauterine RBC transfusions in more detail.

Presented by
David Anderson, DO
Pathology Resident-PGY1 AP/CP, Spencer Fox Eccles School of Medicine at the University of Utah

This video is 17 min

This lecture talks about introductory antibody identification.

Presented by 
Justin R. Rhees, MS, MLS(ASCP)^CM, SBB^CM
Assistant Professor, Medical Laboratory Sciences, University of Utah

This video is 17 min

The ABO blood group system is the most important in transfusion medicine. This presentation covers basic ABO inheritance, antigen production and expression, and weak subgroups.

Presented by 
Justin R. Rhees, MS, MLS(ASCP)^CM, SBB^CM
Assistant Professor, Medical Laboratory Sciences, University of Utah

This video is 45 min

The Rh blood group system is one of the largest and most polymorphic. This lecture describes several Rh antigens and antibodies of clinical significance, Weak D phenotypes, and rare phenotypes that result from deletions and gene mutations.

Presented by
Justin R. Rhees, MS, MLS(ASCP)^CM, SBB^CM
Assistant Professor, Medical Laboratory Sciences, University of Utah

This video is 49 min

A 61 year-old male with HTN transferred from an OSH with MET, acidosis, AKI, and hypoglycemia in the setting of severe malaria and an incidental COVID infection 5 days after returning from Mazambique. No malaria prophylaxis taken. Smear showed Plasmodium falciparum, parasitemia, 24.4%, for which he was started on Artesunate q12h x3 doses, then daily until parasitemia was <1% followed by coatem BID x3 days. Post coatem, he began to feel more fatigued with intermittent mild fevers and darkening urine. He became HDS and aferbrile, but his CBC was notable for a Hgb of 5.1 with PLT of 363. This presentation will further explore this case along with discussing post-artesunate delayed hemolysis in greater detail.

Presented by
David Anderson, DO
Pathology Resident-PGY1 AP/CP, Spencer Fox Eccles School of Medicine at the University of Utah

This video is 21 min

The collection and processing of blood products often requires manipulation and transfer of the blood products between various containers. The sterile tubing welder provides technology for connecting sterile blood containers without compromising the sterility of the fluid pathway and maintaining a functionally closed system. This tutorial will cover the sterile tubing welding process.

Developed by the Institute for Learning, ARUP Laboratories

This lecture talks about Reporting Errors.

This video is 14 minutes

This lecture will cover identifying ABO discrepancies, describe several causes of these discrepancies, and include necessary follow-up testing that is required in the resolution of these discrepancies.

Presented by 
Justin R. Rhees, MS, MLS(ASCP)^CM, SBB^CM
Assistant Professor, Medical Laboratory Sciences, University of Utah

This video is 52 min

This lecture talks about SOPs for cGMPs.

Presented by Rebecca Whitney, MLS (ASCP)
Quality and Compliance Coordinator, Transfusion Medicine, ARUP Laboratories

This video is 10 min

The Lewis system is unique among blood group systems in that the antigens are not manufactured within the erythrocyte, nor do they form an integral part of the cytoskeletal membrane. While antibodies against antigens in this system are fairly commonly encountered, they are generally not considered to be clinically significant in transfusion. Because Lewis phenotype expression is based upon the interaction of several genes, and because the phenotype expression can be transient, the Lewis system is a unique system to learn about.

Presented by
Justin R. Rhees, MS, MLS(ASCP)^CM, SBB^CM
Assistant Professor, Medical Laboratory Sciences, University of Utah

This video is 32 min

Respiratory transfusion reactions occur less frequently than allergic or febrile nonhemolytic transfusion reactions; however, they account for the highest number of transfusion-related fatalities, as actively reported to the FDA in the United States. They are also likely to occur at a rate of 5 to10 times more frequently than the rate currently being passively reported. Careful assessment of patients before, during, and after transfusion is key to mitigating and treating respiratory transfusion reactions. This case-based educational review of transfusion-associated circulatory overload (TACO) and transfusion-related acute lung injury (TRALI) covers the basics of these entities with a practical approach to clinical understanding.

Presented by
Joel Addams, MD
Assistant Professor (Clinical), Spencer Fox Eccles School of Medicine at the University of Utah Medical Director, Transfusion Medicine, ARUP Laboratories

Erica Swenson, DO
Assistant Professor (Clinical), Spencer Fox Eccles School of Medicine at the University of Utah Medical Director, Transfusion Medicine, ARUP Laboratories

This video is 37 min

Respiratory transfusion reactions occur less frequently than allergic or febrile nonhemolytic transfusion reactions; however, they account for the highest number of transfusion-related fatalities, as actively reported to the FDA in the United States. They are also likely to occur at a rate of 5 to10 times more frequently than the rate currently being passively reported. Careful assessment of patients before, during, and after transfusion is key to mitigating and treating respiratory transfusion reactions. This case-based educational review of transfusion-associated circulatory overload (TACO) and transfusion-related acute lung injury (TRALI) covers the basics of these entities with a practical approach to clinical understanding.

Presented by
Joel Addams, MD
Assistant Professor (Clinical), Spencer Fox Eccles School of Medicine at the University of Utah
Medical Director, Transfusion Medicine, ARUP Laboratories

Erica Swenson, DO
Assistant Professor (Clinical), Spencer Fox Eccles School of Medicine at the University of Utah
Medical Director, Transfusion Medicine, ARUP Laboratories

This video is 34 min

This lecture talks about Transfusion Service and Blood Services Operations.

Presented by 
Rebecca Whitney, MLS (ASCP)
Quality and Compliance Coordinator, Transfusion Medicine, ARUP Laboratories

This video is 9 min