Testing a Test: Beyond Sensitivity and Specificity

This lecture covers performance evaluation of diagnostic tests. Traditional performance measures such as sensitivity, specificity, and ROC curves are reviewed. Reasons for differences in diagnostic studies are examined including real differences, threshold effects, sources of bias, and random variation. Shortcomings of the traditional approaches to test evaluation are also discussed and alternative approaches such as diagnostic research (vs test research), clinical trial evaluation, and cost-effectiveness evaluation are presented.

Presented by
Robert Schmidt, MD, PhD, MBA

Associate Professor of Pathology, Spencer Fox Eccles School of Medicine at the University of Utah
Director, Center for Effective Medical Testing, Department of Pathology, Spencer Fox Eccles School of Medicine at the University of Utah
Medical Director, Huntsman Cancer Hospital Clinical Laboratory
Director, Quality Optimization, ARUP Laboratories


Subscribe to our MLS Education Newsletter for the latest news regarding our educational resources.

Click to Subscribe
Your information will not be shared externally.


Comments and Feedback

To provide the highest quality information and educational content, we welcome your comments and feedback. We would also like to extend the invitation and encourage you to collaborate with us to create new content as we work to enhance the value of this resource to all MLS programs. Feel free to contact:

Alyssa Peña, MLS(ASCP)CM
800-242-2787 ext. 3952
Distance Education Coordinator
ARUP Laboratories