Diagnosis of Monoclonal Gammopathies


Monoclonal gammopathies are diagnosed by a triad of criteria including clinical symptoms of the disease, bone marrow analysis and clinical laboratory testing. Protein electrophoresis and immunofixation in serum and urine are the most common tests in clinical laboratory for diagnosis of monoclonal gammopathies. More recently, serum free light chain testing has become an important tool for diagnosis and prognosis of these conditions. The indications and limitation of these clinical laboratory tests are reviewed in this presentation.

Originally presented on January 24, 2011, in Salt Lake City, Utah.

Lecture Presenter

Julio Delgado, MD, MS

Julio Delgado, MD, MS

Assistant Professor of Pathology
University of Utah School of Medicine
Medical Director, Immunology
ARUP Laboratories
Associate Director H & I Laboratory
University of Utah Health Care

Dr. Delgado is an Assistant Professor of Pathology at the University of Utah School of Medicine. He received his M.D. from Universidad Industrial de Santander in Colombia, clinical residency training in Clinical Pathology and research fellowship in Immunology from Harvard Medical School. He received his M.S. degree in Epidemiology from Harvard School of Public Health.

Dr. Delgado is board certified in Clinical Pathology and Histocompatibility laboratory testing by the American Board of Pathology and the American Board of Histocompatibility and Immunogenetics.


After this presentation, participants will be able to:

  • Review clinical laboratory tests available for diagnosis of monoclonal gammopathies.
  • Review clinical presentation and diagnostic criteria of most common monoclonal gammopathies.

Sponsored by:

University of Utah School of Medicine, and ARUP Laboratories