MLS Topics

An 86 year-old male, O+, with a history of anemia presented with extreme fatigue in 2020 and significant weight loss. BMBx found erythroid megloblasoid maturation and abnormal cytogenetics. Diagnosed with low-grade Myelodysplastic syndrome. Severe anemia a year later, repeated BMBx and did not met MDS criteria. This presentation will further discuss the patient's case and labs along with diving into autoimmune hemolytic anemia.

Presented by 
Taylor S. Jackson, DO
Pathology Resident-PGY4; Spencer Fox Eccles School of Medicine at the University of Utah

This video is 18 min

This interactive course will walk you through a simulation of the ELISA test. You will be able to perform each step involved in the procedure to help you become familiar with this assay.

Developed by the Institute for Learning, ARUP Laboratories

Most immunodeficiencies leading to increased susceptibility to infections seen in clinical practice are secondary to other diseases, such as infections (e.g. HIV) and malignancies (e.g. Multiple Myeloma), or are iatrogenic (e.g. immunosuppressive drugs). Primary immunodeficiency diseases (PIDD) are thought to be genetic in origin. There are now over 150 PIDD recognized, and their number is still growing. Most of these diseases are individually rare, but as group they have an estimated prevalence of 1:1200 in the USA, similar to acute leukemias. Diagnosis of PIDDs requires integration of data from clinical findings with laboratory immunological analyses and increasingly with genetic testing. In this presentation we discuss the utility of molecular diagnosis in immunodeficiency diseases, and then review specific examples of genetic susceptibility to bacterial, fungal and viral infections. Immunodeficiencies are often though to lead to ‘opportunistic’ infections. The diseases presented demonstrated that PIDDs can lead to very specific infections.

Presented by 
Attila Kumánovics, MD
Assistant Professor, Department of Pathology, Spencer Fox Eccles School of Medicine at the University of Utah
Assistant Medical Director, Immunology Laboratory, Co-Director, Immunogenetics Laboratory, ARUP Laboratories

This video is 40 min

This lecture reviews the epidemiology as well as the pathophysiological progression of HIV infection. It further explores the evolution of clinical assays for HIV diagnosis, tracing their development from the early stages of the HIV epidemic to current testing approaches and diagnostic algorithms. Light is also shed on testing and diagnosis of HIV infection in special populations such as neonates. The lecture concludes by examining HIV therapy and management strategies, encompassing aspects such as pre- and postexposure prophylaxis.

Presented by 
Kwaku Baryeh, PhD
Former Clinical Chemistry Fellow, Spencer Fox Eccles School of Medicine at the University of Utah

This video is 58 Min

In this lecture, Barbara Bonke MS, MT(ASCP)SI describes the difference between hypersensitivities and allergies, the different types of immune responses and specifics about type I hypersensitivities.

Presented by
Barbara Bonke MS, MT(ASCP)SI
Education Coordinator, Institute for Learning, ARUP Laboratories

This video is 30 min

This lecture describes type II, III and IV hypersensitivities with examples.

Presented by
Barbara Bonke MS, MT(ASCP)SI
Education Coordinator, Institute for Learning, ARUP Laboratories

This video is 32 min

A 70-year-old male presents with on-going nosebleeds. They have a history of hypertension, diabetes mellitus type 2, gout, cronic sinusitis, aortic stenosis s/p aortic valve repair. Diagnosted with ITP ~ 5 to 10 years ago on rituximab. This presention will discuss this patient's diagnosis along with diving into immune thrombovytopenia.

Presented by 
Miranda Chimzar, MD
Pathology Resident-PGY2, Spencer Fox Eccles School of Medicine at the University of Utah

This video is 16 min

This presentation will discuss the principles of flow cytometry, components of the flow cytometer, and applications in the diagnosis and treatment of disease.

Presented by 
John Andreasen, MLS(ASCP)
Laboratory Supervisor, Immunologic Flow Cytometry, ARUP Laboratories

This video is 38 min

This lecture focuses on how Lyme disease is transmitted, how to interpret Lyme disease and symptoms, and diagnosis and laboratory testing.

Presented by 
Ben Bauter
Laboratory Supervisor, Microbial Immunology 1, ARUP Laboratories

This video is 38 min

This lecture discusses the clinical presentation of patients with plasma cell dyscrasias and the assays used to support their diagnosis. Testing methodology and potential interferences are presented in the context of clinical case scenarios.

Presented by
Taylor S. Jackson, DO
Pathology Resident-PGY4, Spencer Fox Eccles School of Medicine at the University of Utah

This video is 57 min