Hepatocellular Carcinoma: Histologic Variants


Discuss the morphologic features of histologic variants of HCC and combined hepatocellular-cholangiocarcinoma with a focus on advantages and pitfalls of various immunohistochemical markers in recognizing the subtypes. The importance of novel markers including molecular alterations in improving the diagnosis will be discussed.

Originally presented on February 5, 2018, in Park City, Utah.

Lecture Presenter

Sanjay Kakar, MD

Sanjay Kakar, MD

Professor of Anatomic Pathology; Chief, Gastrointestinal-Hepatobiliary Pathology Service; Director, Gastrointestinal-Hepatobiliary Pathology Fellowship Program
UCSF School of Medicine

Sanjay Kakar, MD, is professor of pathology, Chief of the GI-liver pathology service, and GI-liver pathology fellowship director at University of California San Francisco. After completing medical school training in India, he attended the University of Illinois in Chicago for pathology residency followed by GI-liver and molecular pathology fellowships at Mayo Clinic, Rochester, MN. He is past president of United States Gastrointestinal Pathology Society, has served on the CAP Surgical Pathology Committee and is currently a member of the CAP Cancer Committee and AJCC staging panel for colorectal and hepatobiliary cancers. His principal research interests are focused on hepatocellular adenoma, hepatocellular carcinoma and colorectal cancer.


After this presentation, participants will be able to:

  • Describe the strengths and limitations of commonly used immunohistochemical markers
  • Explain the criteria for the diagnosis of hepatocellular and cholangiocarcinoma components in combined tumors
  • Enumerate novel immunohistochemical markers and genetic changes that aid in the diagnosis of poorly differentiated carcinomas in the liver

Sponsored by:

University of Utah School of Medicine, Department of Pathology, and ARUP Laboratories