Molecular Tools in the Diagnosis of Lymphoma


Learners will become familiar with current algorithms including immunohistochemistry and FISH testing in the work-up of diffuse large B-cell lymphoma, one of the most common lymphomas a pathologist is likely to encounter in routine practice. We will also discuss B-cell and T-cell clonality testing including how the assays work, when to use them and what the pitfalls are in ordering and interpreting these assays. Learners will leave with a better understanding of how these ancillary tests can be used in the work-up of lymphomas.

Originally presented on February 12, 2019 in Park City, Utah.

Lecture Presenter

Kristin Karner, MD

Kristin Karner, MD

Assistant Professor of Pathology
University of Utah School of Medicine
Medical Director, Hematopathology
ARUP Laboratories

Dr. Karner is an assistant professor of pathology at the University of Utah School of Medicine. She received her MD from the University of Nebraska and completed her anatomic and clinical pathology residency at the University of New Mexico. She also completed hematopathology and molecular genetic pathology fellowships at the University of New Mexico and is board certified by the American Board of Pathology in anatomic and clinical pathology (AP/CP), as well as hematopathology and molecular genetic pathology. Dr. Karner’s areas of focus include both lymphoid and myeloid malignancies, and her current research interests include genetic aspects of myelodysplastic syndrome and other myeloid malignancies.


After this presentation, participants will be able to:

  • Describe common algorithms that incorporate FISH testing in the work up of diffuse large B-cell lymphoma
  • Recognize when it is appropriate to use molecular clonality testing in the work up and diagnosis of lymphoma
  • List the limitations and “pitfalls” of clonality testing

Sponsored by:

University of Utah School of Medicine, Department of Pathology, and ARUP Laboratories