Granulomas in the Liver, with an Emphasis on Infectious Etiologies


Granulomas are aggregates of macrophages, often admixed with other inflammatory cells, which usually result from chronic antigen presentation. Many diseases that produce granulomas involve the liver. Some are intrinsic hepatic diseases, whereas others are disseminated systemic diseases that involve the liver as well as other organs. This lecture emphasizes infectious causes of granulomas, but also discusses non-infectious entities in the differential diagnosis.

Originally published on November 3, 2021

Lecture Presenter

Laura Lamps, MD

Laura Lamps, MD

Godfrey Dorr Stobbe Professor and Director of Gastrointestinal Pathology
Dept. of Pathology, University of Michigan
Patient Safety Officer
University of Michigan Health System

Dr. Laura Webb Lamps, MD is the Godfrey D. Stobbe Professor of Gastrointestinal Pathology at the University of Michigan Department of Pathology, and the first Patient Safety Officer for the University of Michigan Hospital System. Dr. Lamps, originally from Auburn, Alabama, received her B.S. degree from Davidson College, followed by her M.D. from Vanderbilt University in 1992. She also completed her residency and surgical pathology fellowship training at Vanderbilt. She joined the faculty at the University of Arkansas for Medical Sciences (UAMS) in 1998, where until February of 2017 she was Professor of Pathology and Vice Chair for Academic Affairs, as well as the Associate Chief Quality Officer for Risk and Safety.

Dr. Lamps is a renowned academic pathologist and educator, and a leader in the fields of gastrointestinal, hepatic, and infectious disease pathology. She has received multiple teaching awards, and has been invited as a visiting professor or course faculty at over 60 institutions throughout the country and the world. She has authored numerous papers and abstracts, particularly in her primary area of interest, the study of infectious diseases of the liver and GI tract. She is the co-author or author of several major pathology textbooks including Surgical Pathology of the Gastrointestinal System: Bacterial, Fungal, Viral, and Parasitic Infections; Diagnostic Pathology: Normal Histology; and Diagnostic Pathology: GI Endoscopic Correlation. She has also contributed numerous book chapters to texts including Odze and Goldblum’s Surgical Pathology of the Gastrointestinal Tract, Liver, Biliary Tract, and Pancreas, which is regarded as the most widely used GI textbook in the world. She is one of four editors of the recently published 11th edition of Rosai and Ackerman’s Surgical Pathology. Until March of 2017, she served as the chair of the United States and Canadian Academy of Pathology Education Committee.

Dr. Lamps lives in Ann Arbor with her husband, Paul Ward, and their rescue corgi, Henry. She is active in animal welfare efforts, and served on the board and as the past President of the Central Arkansas Rescue Effort for Animals. She is an avid knitter, cook, and substitute yoga instructor.


After this presentation, participants will be able to:

  • Use the morphologic features of granulomas to evaluate liver specimens and make diagnoses
  • Use the appropriate ancillary laboratory tests to aid in the diagnosis of infectious diseases
  • Generate a differential diagnosis for both infectious and noninfectious causes of granulomatous liver disease

Sponsored by:

University of Utah School of Medicine, Department of Pathology, and ARUP Laboratories