An Update on HPV Versus Non-HPV-Associated Endocervical Adenocarcinoma


Recent studies have focused on more detailed characterizations of endocervical adenocarcinomas which are not HPV driven. Additionally, the 5th edition of the WHO Classification of Tumours-Female Genital Tumours has been recently released. Using clinical cases, this presentation aims to highlight recent updates in the morphologic diagnosis and workup of both HPV-associated and HPV-independent invasive endocervical adenocarcinomas.

Originally published on August 9, 2022

Lecture Presenter

Lesley C. Lomo, MD

Lesley C. Lomo, MD

Associate Professor of Pathology (Clinical)
University of Utah School of Medicine
Medical Director, Anatomic Pathology
ARUP Laboratories

Dr. Lomo is an associate professor of pathology at the University of Utah School of Medicine. She received her medical degree from Wayne State University School of Medicine in Detroit and completed her residency in anatomic and clinical pathology, as well as fellowships in women’s and perinatal pathology, breast pathology, and cytopathology at Brigham and Women’s Hospital in Boston. Dr. Lomo is board certified in anatomic and clinical pathology and cytopathology. She is a member of several professional organizations, including the United States and Canadian Academy of Pathology, the American Society for Clinical Pathology, and the International Society of Gynecological Pathologists. Her research interests include education techniques for pathology trainees and medical students, neoplastic and non-neoplastic endometrial pathology, and biomarkers of malignancy risk in preneoplastic epithelial breast disease.


After this presentation, participants will be able to:

  • Describe updates from the 5th edition of the WHO Classification of Tumours-Female Genital Tumours (Uterine Cervix)
  • Recognize HPV-associated adenocarcinomas of the endocervix pattern-based assessment of invasive carcinoma (Silva classification)
  • Identify HPV-independent adenocarcinomas of the endocervix based on International Endocervical Adenocarcinoma Criteria and Classification (IECC) and proposed algorithmic workup

Sponsored by:

University of Utah School of Medicine, Department of Pathology, and ARUP Laboratories