Hematopathology Expert Series
State of Hematopathology: The Past, Present, and the Future

Dr. George will discuss the evolution of hematopathology diagnosis with microscopic analysis (blood, bone marrow, and solid tissue) providing the initial framework of hematopathology. Subtypes were further defined initially based on phenotypic attributes, which were assessed by immunohistochemistry and subsequently by flow cytometry. The field gradually moved away from a pure cell of origin classification to a more integrated approach, and molecular subtypes were described. This revolutionized the field through better prognostication and personalized therapy, as novel therapeutics began to be considered in lieu of or in combination with standard chemotherapy. The advent of high-throughput sequencing/next generation sequencing (NGS) led to major advances with the discovery of mutations. NGS was quickly integrated into the clinical testing environment and is now routinely used in the world of myeloid neoplasms; several institutions also offer NGS for lymphomas. This webinar will also cover current and future uses of digital pathology and artificial intelligence in the world of hematopathology. Finally, Dr. George will conclude with a brief assessment of the International Consensus Classification and the World Health Organization classifications and discuss practical approaches to a more integrated hematopathology diagnostic process.

Originally presented on August 29, 2023, in Salt Lake City, Utah.

Lecture Presenters

Tracy I. George, MD Professor (Clinical) University of Utah School of Medicine President and Chief Scientific Officer; Medical Director, Hematopathology ARUP Laboratories

Dr. Tracy I. George is the President and Chief Scientific Officer at ARUP Laboratories. She is also a professor of pathology at the University of Utah School of Medicine. Dr. George graduated from the University of California, San Francisco School of Medicine with her medical degree before completing a pathology and laboratory medicine residency at the same location. She continued to complete both a hematopathology and a surgical pathology fellowship at Stanford University School of Medicine. She is certified by the American Board of Pathology in hematology and anatomic and clinical pathology. Dr. George is President of the International Society for Laboratory Hematology and the recipient of the Lifetime Achievement Award from the College of American Pathologists. Her research interests include mast cell disease, translational hematopathology, and laboratory hematology.

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Madhu P. Menon, MD, PhD, FCAP Associate Professor (Clinical) University of Utah School of Medicine Section Chief, Hematopathology ARUP Laboratories

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Archana Mishra Agarwal, MD Professor (Clinical) University of Utah School of Medicine Medical Director, Hematopathology and Special Genetics ARUP Laboratories

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Robert S. Ohgami, MD, PhD Professor University of Utah School of Medicine Chief Medical Director, Research and Development in Integrated Oncology and Genetics ARUP Laboratories

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Objectives

After this presentation, participants will be able to:

• Describe the two major classification systems for hematolymphoid neoplasms
• Define the components of an integrated hematopathology diagnostic report
• Discuss ways digital pathology and artificial intelligence can be used in hematopathology

Sponsored by:

University of Utah School of Medicine, Department of Pathology, and ARUP Laboratories