Intraductal Proliferative Lesions of the Breast


This presentation deals with the changing interpretation of intraductal proliferative lesions of the breast over the years and the current evidence for and against their relative precancerous nature.

Originally presented as a pre-recorded lecture on February 09, 2015 in Park City, Utah.

Originally published on July 21, 2015

Lecture Presenter

Juan Rosai, MD

Juan Rosai, MD

Associate Medical Director, Cytopathology and Surgical Pathology
ARUP Laboratories
Assistant Professor of Pathology
University of Utah School of Medicine

Dr. Rosai received his MD at the University of Buenos Aires School of Medicine in Argentina, and completed his pathology residency at the Hospital Regional Mar del Plata in Argentina and at the Washington University School of Medicine and Barnes Hospital in St. Louis, Missouri, where he also attained his fellowship training in surgical pathology under Dr. Lauren V. Ackerman.

Dr. Rosai’s awards and honors include the highest accolades in pathology, including the USCAP President’s Award in 2012, the IAP Pathology Gold Medal for outstanding contributions in international pathology education and research in 2010, the USCAP Distinguished Pathologist Award in 2010, the American Board of Pathology’s Life Trustee status in 2007, the USCAP Maude Abbott Lectureship in 1995, and the Liebow Award for excellence in teaching at Yale University in 1988.

He has served as editor in chief for the third series of the AFIP Fascicles and is the current editor in chief of The International Journal of Surgical Pathology, among 24 additional editorial boards during 48 years of editorial service. During his career, Dr. Rosai has published 52 books, book chapters, and monographs, and a staggering total of more than 390 peer-reviewed papers. He is the primary author of the world’s preeminent textbook of surgical pathology, translated into Spanish, Chinese, and Croatian, which carries in its title the name of his mentor, Rosai and Ackerman’s Surgical Pathology, a 10th edition of which was issued in 2011.


After this presentation, participants will be able to:

  • To distinguish usual ductal hyperplasia from atypical ductal hyperplasia and low-grade intraductal carcinoma.
  • To become familiarized with breast lesions belonging to the columnar cell change and flat epithelial atypia categories.
  • To list the points for and against the two major classifications of intraductal proliferative lesions of the breast (WHO and DIN).

Sponsored by:

University of Utah School of Medicine, Department of Pathology, and ARUP Laboratories