It Takes a Village: A Comprehensive Approach to Myeloproliferative Neoplasms

 

Myeloproliferative neoplasms (MPNs) are a group of myeloid disorders that usually presents with elevated peripheral blood counts, hepatosplenomegaly and genetic alterations of tyrosine kinase genes. Due to a significant overlap in clinical, morphologic and laboratory findings, diagnostic workup of these patients is complicated and requires integration of numerous diagnostic modalities. Although certain genetic alterations are preferentially enriched in specific MPN types lacking the Philadelphia chromosome, none of them are disease defining; therefore, a thorough workup should always include a bone marrow biopsy for morphologic evaluation and diagnosis. This lecture will focus on specific bone marrow morphologic findings associated with MPNs, as well as on the importance of a comprehensive approach for accurate diagnosis and prognosis.

Originally presented on February 6, 2023, in Park City, Utah.

Lecture Presenter

Olga Pozdnyakova, MD, PhD

Olga Pozdnyakova, MD, PhD

Associate Pathologist
Brigham and Women's Hospital
Associate Medical Director of the Clinical Hematology Laboratory
Brigham and Women’s Hospital
Medical Director
Physicians Diagnostic Labs
Associate Professor, Pathology
Harvard Medical School

Dr. Olga Pozdnyakova is an associate professor of pathology at Harvard Medical School and a diagnostic hematopathologist at Brigham and Women’s Hospital/Dana Farber Cancer Institute. She serves as the medical director of the Hematology Laboratory at Brigham and Women’s Hospital and Physician Diagnostics Labs at the Brigham Health Harbor Medical Associates. Dr. Pozdnyakova is an author of over 90 peer-reviewed publications and reviews. She has authored chapters on the topic of myeloid neoplasm in several fundamental pathology textbooks, such as Diagnostic Histopathology of Tumors, Wintrobe’s Atlas of Clinical Hematology, Diagnosis of Blood and Bone Marrow Disorders, and Diagnostic Bone Marrow Hematopathology, and is a coauthor of the textbook Hematopathology: A Volume in the High Yield Pathology Series. She serves as a vice-chair of the College of American Pathologists Clinical Hematology and Microscopy Committee. Dr. Pozdnyakova has lectured on various topics at numerous national and international pathology meetings and educational courses.

Objectives

After this presentation, participants will be able to:

  • Recognize blood and/or bone marrow morphologic findings associated with MPNs
  • Accurately apply bone marrow fibrosis grading and understand its significance
  • Discuss the importance of a comprehensive approach for diagnosis and prognosis of MPNs

Sponsored by:

University of Utah School of Medicine, Department of Pathology, and ARUP Laboratories