Re-examining Fundamental Concepts in Transfusion Medicine


Although the development of alloantibodies can cause significant morbidity and mortality in transfusion-dependent patients, the immunological processes the govern the development of alloantibodies following transfusion and the consequences of alloantibody formation are not completely understood. 1This lecture will examine key immune factors that regulate the development of alloantibodies following blood transfusion, while also assessing important factors that influence the consequences of alloantibodies on incompatible blood transfusion.

Originally published on June 9, 2021

Lecture Presenter

Sean Stowell, MD, PhD

Sean Stowell, MD, PhD

Medical Director, Center for Apheresis
Emory Hospital
Medical Director, Laboratory and Blood Bank
Emory Orthopaedics and Spine Hospital, Center for Transfusion and Cellular Therapies, Emory University School of Medicine

Dr. Sean Stowell received his MD and PhD degrees from Emory, where he graduated Summa Cum Laude. He then stayed at Emory to obtain clinical training in laboratory and transfusion medicine. His research laboratory studies the factors that regulate the development and consequences of alloantibody formation following blood transfusion. He is currently a principal investigator and has four active grants. Dr. Stowell sits on the editorial board of Transfusion and is a reviewer for Blood, The Journal of Experimental Medicine, Journal of Immunology, Transfusion, Scientific Reports, Journal of Leukocyte Biology, Proteomics, and Glycobiology. He is an associate professor in the Department of Pathology and Laboratory Medicine at the Emory University School of Medicine. Clinically, he is the Medical Director of the Apheresis Center at Emory University Hospital.


After this presentation, participants will be able to:

  • Describe the immune factors that may regulate the development of alloantibodies following blood transfusion
  • Describe the varying consequences of incompatible blood transfusion

Sponsored by:

University of Utah School of Medicine, Department of Pathology, and ARUP Laboratories