Diagnosing Systemic Mastocytosis: For Allergists/Immunologists

This lecture offers the following credit types: CME, P.A.C.E.®
 

This lecture reviews the diagnosis of systemic mastocytosis specifically aimed at allergists and immunologists. Topics discussed will include classification systems for mastocytosis, subtypes of systemic mastocytosis, the immunohistochemistry and molecular diagnosis of systemic mastocytosis, hereditary alpha-tryptasemia, and the challenges of diagnosis encountered in nonadvanced systemic mastocytosis.

Originally published on August 25, 2025

Lecture Presenter

Tracy I. George, MD

Tracy I. George, MD

Professor (Clinical)
University of Utah School of Medicine
Chief Scientific Officer; President, Innovation Business Unit; Medical Director, Hematopathology
ARUP Laboratories

Dr. Tracy I. George is the chief scientific officer and the president of the Innovation Business Unit at ARUP Laboratories. She is also a professor of pathology at the University of Utah School of Medicine. Dr. George graduated from the University of California, San Francisco School of Medicine with her medical degree before completing a pathology and laboratory medicine residency at the same location. She then completed fellowships in hematopathology and surgical pathology at Stanford University School of Medicine. She is certified in hematology and anatomic and clinical pathology by the American Board of Pathology. Dr. George is the past president of the International Society for Laboratory Hematology and is currently serving as the secretary/treasurer of the American Initiative in Mast Cell Diseases (AIM). She is the recipient of the Lifetime Achievement Award from the College of American Pathologists. Her research interests include mast cell disease, translational hematopathology, and laboratory hematology.

Objectives

After this presentation, participants will be able to:

  • Describe the pathogenesis of systemic mastocytosis
  • Understand how hereditary alpha-tryptasemia influences the basal serum tryptase level and the impacts on the diagnosis of systemic mastocytosis
  • Define the three subtypes of non-advanced systemic mastocytosis

Sponsored by:

University of Utah School of Medicine, Department of Pathology, and ARUP Laboratories