Pitfalls in the Diagnosis of Hematologic Conditions

 

This presentation will cover syphilis, myeloid sarcoma and liposarcoma mimickers that might be misdiagnosed in diagnostic hematopathology. Clinical cases with abundant hematoxylin and eosin pictures, accompanied by pertinent immunohistochemical stains will be discussed. Each case will provide clinicopathologic findings, differential diagnosis, and appropriate ancillary testing.

Originally presented on February 7, 2023, in Park City, Utah.

Lecture Presenter

Anna M. Shestakova, MD, PhD

Anna M. Shestakova, MD, PhD

Assistant Professor
University of Utah School of Medicine
Medical Director
Hematopathology, ARUP Laboratories

Dr. Anna Shestakova is a medical director of Hematopathology and Molecular Genetic Pathology at ARUP Laboratories and an assistant professor (clinical) at the University of Utah School of Medicine. She received a medical degree from Bogomolets National Medical University and a doctorate degree from the University of Utah. She completed a residency in anatomical and clinical pathology at the University of California, Irvine School of Medicine, and she completed fellowships in hematopathology at the University of Michigan and molecular genetic pathology at the University of Utah School of Medicine. Dr. Shestakova is certified by the American Board of Pathology in anatomic and clinical pathology and hematopathology. She is also a member of the Educational Commission for Foreign Medical Graduates. Her research interests include small lymphocytic lymphoma (SLL), chronic lymphocytic leukemia (CLL), and the role of TP53 in the clonal evolution of lymphoid and myeloid neoplasms.

Objectives

After this presentation, participants will be able to:

  • Describe the clinical presentation of syphilis and discuss the hallmarks of histologic presentation of syphilis, the use of treponemal testing in the diagnosis of syphilis, and the differential diagnosis of syphilitic lymphadenitis
  • Describe the clinical presentation of myeloid sarcoma and discuss the hallmarks of histologic presentation of myeloid sarcoma, the use of immunohistochemical and molecular testing in the diagnosis of myeloid sarcoma, and the differential diagnosis of myeloid sarcoma
  • Describe the clinical presentation of liposarcoma and discuss the histology of inflammatory and dedifferentiated liposarcoma, the use of immunohistochemistry and FISH testing in the diagnosis of liposarcoma, and the differential diagnosis of liposarcoma

Sponsored by:

University of Utah School of Medicine, Department of Pathology, and ARUP Laboratories