ICC and WHO Classifications: Follicular, Large, and High-Grade B-Cell Lymphomas



 

This presentation will cover pediatric follicular lymphoma, HGBCL with 11q aberration and HGBCL with MYC, BCL2, BCL6 rearrangements and TdT expression. Clinical cases will include abundant hematoxylin and eosin pictures, accompanied by pertinent immunohistochemical stains. Each case discusses clinicopathologic findings, differential diagnosis and appropriate ancillary testing.

Originally published on November 4, 2024


Lecture Presenter

Anna M. Shestakova, MD, PhD

Anna M. Shestakova, MD, PhD

Assistant Professor (Clinical) of Pathology
University of Utah School of Medicine
Medical Director, Hematopathology and Molecular Genetics
ARUP Laboratories

Dr. Anna Shestakova is a medical director of Hematopathology and Molecular Genetic Pathology at ARUP Laboratories and an assistant professor (clinical) at the University of Utah School of Medicine. She received a medical degree from Bogomolets National Medical University and a doctorate degree from the University of Utah. She completed a residency in anatomical and clinical pathology at the University of California, Irvine School of Medicine, and she completed fellowships in hematopathology at the University of Michigan and molecular genetic pathology at the University of Utah School of Medicine. Dr. Shestakova is certified by the American Board of Pathology in anatomic and clinical pathology and hematopathology. She is also a member of the Educational Commission for Foreign Medical Graduates. Her research interests include small lymphocytic lymphoma (SLL), chronic lymphocytic leukemia (CLL), and the role of TP53 in the clonal evolution of lymphoid and myeloid neoplasms.


Objectives

After this presentation, participants will be able to:

  • Discuss histologic hallmarks of pediatric follicular lymphoma and determine differential diagnosis of pediatric follicular lymphoma
  • Discuss use of immunohistochemical and ancillary testing in the diagnosis of HGBCL with 11q aberration along with differential diagnosis of HGBCL with 11q aberration
  • Describe the clinical presentation, histology, immunophenotype by flow cytometry/immunohistochemistry, and FISH with the differential diagnosis of HGBCL with MYC, BCL2, BCL6

Sponsored by:

University of Utah School of Medicine, Department of Pathology, and ARUP Laboratories