Molecular Subtypes of Renal Cell Carcinomas


Large scale sequencing studies have expanded our understanding of renal cell carcinomas; identifying new information of the genomic landscape across different renal cell carcinoma subtypes. As research in this field unfolds, discoveries from these studies have had significant impact in not only identifying diagnostic molecular alteration, but also prognostic subcategories and therapeutically targetable genomic alterations. This talk will review the emerging genomic landscape of renal cell carcinomas, provide an overview of an integrative approach to molecular subtyping of this subset of tumors and the challenges and limitations of this approach, and address the role of a multi-omics approach in precision medicine for renal cancers.

Originally presented on February 13, 2019, in Park City, Utah.

Lecture Presenter

Deepika Sirohi, MD

Deepika Sirohi, MD

Assistant Professor of Pathology
University of Utah School of Medicine
Medical Director, Molecular Oncology
ARUP Laboratories

Dr. Deepika Sirohi is an assistant professor of pathology at the University of Utah School of Medicine. She received her MD from Armed Forces Medical College in Prune, Maharashtra, India and went on to complete her residency in anatomical and clinical pathology at University of Texas Health Science Center at San Antonio where she served as Co-chief Resident. Dr. Sirohi completed fellowship programs in Genitourinary Pathology at Cedar-Sinai Medical Center and Molecular Genetic Pathology at the University of California San Francisco. She is board certified by the American Board of Pathology in Anatomical and Clinical Pathology. Her research interests include genomic alterations in urologic malignancies, viral oncogenesis and application of next generation sequencing to solid tumors.


After this presentation, participants will be able to:

  • Describe the genomic landscape of renal cell carcinoma
  • Apply an integrative approach to molecular subtyping of RCCs
  • Recognize challenges to molecular classification of RCCs

Sponsored by:

University of Utah School of Medicine, Department of Pathology, and ARUP Laboratories