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WHO Updates for Myelodysplastic Syndrome and Myeloproliferative Neoplasms

 

This presentation will cover WHO updates for both myelodysplastic syndromes and myeloproliferative neoplasms. For myelodysplastic syndromes, emphasis will be placed on the role of somatic gene mutation testing in the diagnosis and prognostication. The challenge of distinction of myelodyspslastic syndromes from preclinical states characterized by clonal hematopoiesis will be discussed. As for updates related to myeloproliferative neoplasms (MPNs), categories have not changed significantly except the exclusion of mastocytosis. Mastocytosis is now a separate category due to its unique clinical and pathologic features. The update will focus on the molecular as well as the clinical and pathological changes that have been incorporated into the current diagnostic categories of MPNs.

Originally presented on February 6, 2017, in Park City, Utah.

Lecture Presenters

Jay L. Patel, MD

Jay L. Patel, MD

Associate Professor of Pathology
University of Utah School of Medicine
Medical Director, Hematopathology Laboratory
ARUP Laboratories

Dr. Patel is an associate professor of pathology at the University of Utah School of Medicine. He received his MD from the University of Arizona and completed a residency in anatomic and clinical pathology at the University of Utah. Dr. Patel then served as a hematopathology fellow at Stanford University. He is certified by the American Board of Pathology in anatomic and clinical pathology, with subspecialty boards in hematology, and is a member of the CAP Hematology & Clinical Microscopy Resource Committee. Dr. Patel’s clinical and research interests are broad and include all aspects of hematopathology. He is keen on application of next-generation sequencing technologies in the diagnosis and prognostication of hematolymphoid malignancies and benign hematologic disorders.

Archana Agarwal, MD

Archana Agarwal, MD

Associate Professor of Pathology
University of Utah School of Medicine
Medical Director, Hematopathology and Special Genetics
ARUP Laboratories

Dr. Agarwal is an associate professor of pathology at the University of Utah School of Medicine. She received her MD at Delhi University in India and was a postdoctoral research scholar at the University of Iowa. She served as a pathology resident, a hematopathology fellow, and a molecular genetics pathology fellow at the University of Utah School of Medicine. Dr. Agarwal is board certified in hematopathology, anatomic pathology, and clinical pathology. She is also a member of several professional societies, including the College of American Pathologists and the American Society for Clinical Pathology. Dr. Agarwal’s research interests include red-cell enzymopathies, hemoglobinopathies, and molecular hematopathology.

Objectives

After this presentation, participants will be able to:

  • Review current diagnostic criteria pertaining to myelodysplastic syndromes.
  • Understand the relevance of selected somatic gene mutations in the diagnosis and prognostication of myelodysplastic syndromes.
  • Review the new molecular findings that have been incorporated into the diagnostic algorithms of MNNs
  • Understand the morphological difference between essential thrombocythemia (ET) and preprimary myelofibrosis (PMF)

Sponsored by:

University of Utah School of Medicine, Department of Pathology, and ARUP Laboratories