Clinical Flow Cytometry for the Perplexed-Part 4: Leukemias and Myeloid Neoplasms

 

This lecture covers acute leukemias and myeloid neoplasm, particularly phenotypes that help with lineage assignation as well as phenotypic properties seen in translocation defined AMLs. Of particular interest is knowledge of maturation sequences of myeloid and lymphoid progenitors – a topic that needs to be well understood for both MRD and MDS analysis.

Originally published on February 2, 2022

Lecture Presenter

David P. Ng, MD

David P. Ng, MD

Assistant Clinical Professor
University of Utah School of Medicine
Medical Director, Hematopathology
ARUP Laboratories

Dr. David P. Ng is a medical director of hematopathology at ARUP Laboratories and an assistant clinical professor of pathology at the University of Utah. Dr. Ng received his medical degree from the University of Illinois at Chicago College of Medicine. He then completed an anatomic and clinical pathology residency at Dartmouth-Hitchcock Medical Center and a hematopathology fellowship at the University of Washington. Dr. Ng is board certified in anatomic and clinical pathology and hematology. He is the recipient of the Janis Giorgi Young Investigator award and the John H. Rippey Grant for Laboratory Quality Assurance. His research interests include minimal residual disease testing, clinical flow cytometry, and deep learning applications in flow cytometry.

Objectives

After this presentation, participants will be able to:

  • Recognize important flow cytometric phenotypes among acute myeloid leukemias
  • Discuss the gating strategies needed for diagnosing monocytic and myelomonocytic neoplasms
  • Describe the normal maturational pathways for maturing myeloid precursors and their potential derangements

Sponsored by:

University of Utah School of Medicine, Department of Pathology, and ARUP Laboratories